Article
The transcription factor Pitx3 is a risk modifier for Parkinson's disease in a Chinese Han population.
European journal of neurology - 1 May 2011
Yu L-H, Lin Z-F, Liu Y, Hu F-Y, He X-H, Liu Z-L, Xu Y-M
Abstract excerpt
BACKGROUND AND PURPOSE: The transcription factor Pitx3 plays a crucial role in the development and survival of midbrain dopaminergic (mDA) neurons, especially the mDA neurons in the substantia nigra pars compacta. The degeneration of these neurons is the pathological hallmark in Parkinson's disease (PD). Several polymorphisms of the Pitx3 gene have been linked with sporadic and early-onset forms of PD, but...
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