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Article

The transcription factor PITX3 is associated with sporadic Parkinson's disease.

Neurobiology of aging - 1 May 2009

Fuchs Julia, Mueller Jakob C, Lichtner Peter, Schulte Claudia, Munz Marita, Berg Daniela, Wüllner Ullrich, Illig Thomas, Sharma Manu, Gasser Thomas

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative disease with typical motor symptoms due to the preferential loss of midbrain dopaminergic (mDA) neurons in the Substantia nigra pars compacta. Several proteins of the homeodomain family are crucial for the development of mDA neurons. These proteins remain expressed into adulthood with largely unknown functions, but potentially influence mDA neuronal...

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Source

Identifiers

PMID: 17905480
DOI: 10.1016/j.neurobiolaging.2007.08.014

Genes

PITX3
OTX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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