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Article

Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2006

Martinat Cecile, Bacci Jean-Jacques, Leete Thomas, Kim Jongpil, Vanti William B, Newman Amy H, Cha Joo H, Gether Ulrik, Wang Honggang, Abeliovich Asa

Abstract excerpt

Midbrain dopamine (DA) neurons play a central role in the regulation of voluntary movement, and their degeneration is associated with Parkinson's disease. Cell replacement therapies, and in particular embryonic stem (ES) cell-derived DA neurons, offer a potential therapeutic venue for Parkinson's disease. We sought to identify genes that can potentiate maturation of ES cell cultures to the midbrain DA neuron...

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Identifiers

PMID: 16477036
DOI: 10.1073/pnas.0511153103
PMCID: PMC1413837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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