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Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival.

Stem cells (Dayton, Ohio) - 31 Mar 2010

Lee Hyun-Seob, Bae Eun-Ji, Yi Sang-Hoon, Shim Jae-Won, Jo A-Young, Kang Jin-Sun, Yoon Eun-Hye, Rhee Yong-Hee, Park Chang-Hwan, Koh Hyun-Chul, Kim Hyun-Jung, Choi Hueng-Sik, Han Jeung-Whan, Lee Yong-Sung, Kim Jaesang, Li Jia-Yi, Brundin Patrik, Lee Sang-Hun

Abstract excerpt

Effective dopamine (DA) neuron differentiation from neural precursor cells (NPCs) is prerequisite for precursor/stem cell-based therapy of Parkinson's disease (PD). Nurr1, an orphan nuclear receptor, has been reported as a transcription factor that can drive DA neuron differentiation from non-dopaminergic NPCs in vitro. However, Nurr1 alone neither induces full neuronal maturation nor expression of proteins found...

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PMID: 20049900
DOI: 10.1002/stem.294

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