Article
Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons.
Development (Cambridge, England) - 1 Dec 2011
Jacobs Frank M J, Veenvliet Jesse V, Almirza Wadia H, Hoekstra Elisa J, von Oerthel Lars, van der Linden Annemarie J A, Neijts Roel, Koerkamp Marian Groot, van Leenen Dik, Holstege Frank C P, Burbach J Peter H, Smidt Marten P
Abstract excerpt
Development of meso-diencephalic dopamine (mdDA) neurons requires the combined actions of the orphan nuclear receptor Nurr1 and the paired-like homeobox transcription factor Pitx3. Whereas all mdDA neurons require Nurr1 for expression of Th and survival, dependence on Pitx3 is displayed only by the mdDA subpopulation that will form the substantia nigra (SNc). Previously, we have demonstrated that Pitx3(-/-)...
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