Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

6-mercaptopurine influences TPMT gene transcription in a TPMT gene promoter variable number of tandem repeats-dependent manner.

Pharmacogenomics - 1 Feb 2012

Kotur Nikola, Stankovic Biljana, Kassela Katerina, Georgitsi Marianthi, Vicha Anna, Leontari Iliana, Dokmanovic Lidija, Janic Dragana, Krstovski Nada, Klaassen Kristel, Radmilovic Milena, Stojiljkovic Maja, Nikcevic Gordana, Simeonidis Argiris, Sivolapenko Gregory, Pavlovic Sonja, Patrinos George P, Zukic Branka

Abstract excerpt

AIM: TPMT activity is characterized by a trimodal distribution, namely low, intermediate and high methylator. TPMT gene promoter contains a variable number of GC-rich tandem repeats (VNTRs), namely A, B and C, ranging from three to nine repeats in length in an A(n)B(m)C architecture. We have prev...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to K562 Cells
Share to Mercaptopurine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyltransferases

Share to Minisatellite Repeats

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Promoter Regions, Genetic

Share to Transcription, Genetic

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 22304581
DOI: 10.2217/pgs.11.153

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22304581-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

6-mercaptopurine influences TPMT gene transcription in a TPMT gene promoter variable number of tandem repeats-dependent manner.PMID 22304581Read ↗

Functional Analysis of the Role of the<i>TPMT</i>Gene Promoter VNTR Polymorphism in<i>TPMT</i>Gene TranscriptionSemantic proximity Read ↗

Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond.Semantic proximity Read ↗

The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.Semantic proximity Read ↗

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Recent advances in the pharmacogenomics of thiopurine methyltransferase.Semantic proximity Read ↗

Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity.Semantic proximity Read ↗

Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia.Semantic proximity Read ↗

Role of TPMT and ITPA variants in mercaptopurine disposition.Semantic proximity Read ↗

Effects of <i>NT5C2</i> germline variants on 6-mecaptopurine metabolism in children with acute lymphoblastic leukemiaSemantic proximity Read ↗

Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL.Semantic proximity Read ↗

Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.Semantic proximity Read ↗

The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.