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Article

The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.

Pharmacogenomics - 1 Jan 2002

McLeod Howard L, Siva Chokkalingam

Abstract excerpt

Thiopurine methyltransferase catalyzes the S-methylation of azathioprine (AZA), 6-mercapto-purine (6-MP) and thioguanine, medications widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease and solid organ transplant rejection. TPMT activity exhibits a genetic polymorphism in 10% of Caucasians, with 1/300 individuals having complete deficiency. Patients with...

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Source

Identifiers

PMID: 11966406
DOI: 10.1517/14622416.3.1.89

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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