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Article

Recent advances in the pharmacogenomics of thiopurine methyltransferase.

The pharmacogenomics journal - 1 Jan 2001

Coulthard S A, Hall A G

Abstract excerpt

The thiopurine drugs (6-mercaptopurine, 6-thioguanine and azathioprine) are commonly used cytotoxic agents and immunosuppressants. One important route for the metabolism of these agents is methylation, mediated by thiopurine methyltransferase (TPMT). It is now well established that inter-individual variation in sensitivity to thiopurines can be due to the presence of common genetic polymorphisms affecting the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11908768
DOI: 10.1038/sj.tpj.6500066

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variation in the MTHFR gene influences thiopurine methyltransferase activity.Semantic proximity Read ↗

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