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Article

Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL.

Pharmacogenomics - 1 Jul 2012

Dorababu Patchva, Naushad Shaik Mohammad, Linga Vijay Gandhi, Gundeti Sadashivudu, Nagesh Narayana, Kutala Vijay Kumar, Reddanna Pallu, Digumarti Raghunadharao

Abstract excerpt

AIM: The rationale of this study was to explore the contribution of genetic variants of the folate pathway to toxicity of 6-mercaptopurine (6-MP)-mediated hematological toxicity in children with acute lymphoblastic leukemia (ALL) and to explore the interaction of these variants with TPMT and ITPA haplotypes using multifactor dimensionality reduction analysis. MATERIALS & METHODS: Children with ALL (n = 96) were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22838948
DOI: 10.2217/pgs.12.70

Genes

RFC1
TPMT
TYMS
ITPA
MTHFR
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL.PMID 22838948Read ↗

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