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Article

Functional Analysis of the Role of the<i>TPMT</i>Gene Promoter VNTR Polymorphism in<i>TPMT</i>Gene Transcription

29 Mar 2010

Abstract excerpt

AIMS: Thiopurine S-methyltransferase (TPMT) activity is polymorphic, and a trimodal distribution has been demonstrated in Caucasians (low, intermediate and high methylator groups). The TPMT gene promoter contains a variable number of three GC-rich tandem repeats, namely A, B and C, ranging from three to nine in length in a A(n)B(m)C architecture. MATERIALS & METHODS: Here, we investigated the influence of number...

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PMID: 20350137
DOI: 10.2217/pgs.10.7

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