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Article

Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity.

Clinical pharmacology and therapeutics - 1 Aug 2001

Alves S, Amorim A, Ferreira F, Prata M J

Abstract excerpt

BACKGROUND: The genetic polymorphism of thiopurine methyltransferase (TPMT) activity has a significant relevance in the clinical outcome of patients receiving thiopurine drugs as immunosupressive or anticancer therapies. Apart from several open reading frame mutations unequivocally associated with decreased TPMT activity, a variable number of tandem repeats (VNTR), located within the 5' untranslated region, was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11503011
DOI: 10.1067/mcp.2001.117284

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity.PMID 11503011Read ↗

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Genetic polymorphism of thiopurine S-methyltransferase in Argentina.Semantic proximity Read ↗

Genetic determinants of the pre- and post-azathioprine therapy thiopurine methyltransferase activity phenotype.Semantic proximity Read ↗

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Screening of thiopurine S-methyltransferase mutations by horizontal conformation-sensitive gel electrophoresis.Semantic proximity Read ↗

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