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Article

Role of TPMT and ITPA variants in mercaptopurine disposition.

Cancer chemotherapy and pharmacology - 1 Mar 2018

Gerbek Tina, Ebbesen Maria, Nersting Jacob, Frandsen Thomas L, Appell Malin Lindqvist, Schmiegelow Kjeld

Abstract excerpt

PURPOSE: To explore the levels of thioguanine incorporated into DNA (DNA-TG), and erythrocyte levels of 6-thioguanine nucleotides (Ery-TGN) and methylated metabolites (Ery-MeMP) during 6-mercaptopurine (6MP)/Methotrexate (MTX) therapy of childhood acute lymphoblastic leukemia (ALL) and the relation to inosine triphosphatase (ITPA) and thiopurine methyltransferase (TPMT) gene variants. METHODS: Blood samples were...

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Identifiers

PMID: 29387964
DOI: 10.1007/s00280-018-3525-8

Genes

ITPA
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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