Article
Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia.
European journal of clinical pharmacology - 1 Apr 2012
Dorababu Patchva, Nagesh Narayana, Linga Vijay Gandhi, Gundeti Sadashivudu, Kutala Vijay Kumar, Reddanna Pallu, Digumarti Raghunadharao
Abstract excerpt
PURPOSE: To explore the role of genetic variants of thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) in 6-mercaptopurine (6-MP)-induced toxicity in Indian children with acute lymphoblastic leukemia (ALL). METHODS: Children with ALL receiving 6-MP in maintenance phase of treatment (n = 90) were enrolled in the study. Bidirectional sequencing of TPMT (whole gene) and ITPA (exon 2,...
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