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Article

Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond.

Pharmacogenomics - 1 Aug 2009

Karas-Kuzelicki Natasa, Mlinaric-Rascan Irena

Abstract excerpt

The metabolism of a given drug depends, not solely on a particular enzyme, but rather on a complex metabolic network. Thiopurine S-methyltransferase (TPMT) catalyzes the methylation, and thus deactivation, of 6-mercaptopurine, a thiopurine used in the treatment of acute lymphoblastic leukemia. Low TPMT activity has been associated with severe toxicity of 6-mercaptopurine. Determination of mutations in the TPMT...

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Share to Antimetabolites, Antineoplastic
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Inactivation, Metabolic

Share to Mercaptopurine

Share to Methyltransferases

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Identifiers

PMID: 19663675
DOI: 10.2217/pgs.09.78

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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