Article
Effects of sequence variation on differential allelic transcription factor occupancy and gene expression.
Genome research - 1 May 2012
Reddy Timothy E, Gertz Jason, Pauli Florencia, Kucera Katerina S, Varley Katherine E, Newberry Kimberly M, Marinov Georgi K, Mortazavi Ali, Williams Brian A, Song Lingyun, Crawford Gregory E, Wold Barbara, Willard Huntington F, Myers Richard M
Abstract excerpt
A complex interplay between transcription factors (TFs) and the genome regulates transcription. However, connecting variation in genome sequence with variation in TF binding and gene expression is challenging due to environmental differences between individuals and cell types. To address this problem, we measured genome-wide differential allelic occupancy of 24 TFs and EP300 in a human lymphoblastoid cell line...
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