Allelic imbalance assays to quantify allele-specific gene expression and transcription factor binding.

Abstract excerpt

A growing number of noncoding variants are found to influence the susceptibility to common diseases and interindividual variation in drug response. However, the mechanisms by which noncoding variation affects cellular and clinical phenotypes remain to be elucidated. Allele-specific assays allow testing directly the differential properties of the alleles at a regulatory variant, which are detected as an allelic...

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