Article
Characterization of single nucleotide polymorphisms of cytochrome p450 in an Australian deceased sample.
Current drug metabolism - 1 Jun 2012
Pilgrim Jennifer L, Ruiz Yarimar, Gesteira Alejandro, Cruz Raquel, Gerostamoulos Dimitri, Carracedo Angel, Drummer Olaf H
Abstract excerpt
The genetically variable CYP450 isozymes are responsible for the metabolism of up to 80% of commonly used drugs, many of which are detected in cases of unexpected or suspicious death in Australia. The aim of this study was to examine the genetic profiles of individuals in a cohort of Australian deceased individuals dying of drug toxicity (219), natural disease (150), external injury (109) or unascertained (8)...
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