Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetics of the cytochromes P450.

Current topics in medicinal chemistry - 1 Jan 2004

Daly Ann K

Abstract excerpt

The cytochromes P450 are a family of heme-containing proteins with a major role in the oxidation of both xenobiotics (including prescribed drugs) and endogenous compounds. There are at least 57 human P450s (termed isoforms) which are all encoded by separate genes but only 10 of these contribute to drug metabolism, with the major contribution coming from only 3 isoforms, CYP3A4, CYP2D6 and CYP2C9. It is now well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 Enzyme System
Share to Drug-Related Side Effects and Adverse Reactions
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pharmaceutical Preparations

Share to Pharmacogenetics

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 15579105
DOI: 10.2174/1568026043387070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetics of the cytochromes P450.PMID 15579105Read ↗

Pharmacogenetics of the Cytochrome P450 Enzyme System: Review of Current Knowledge and Clinical SignificanceSemantic proximity Read ↗

Cytochrome P450: genotype to phenotypeSemantic proximity Read ↗

Cytochrome P450 in Pharmacogenetics: An Update.Semantic proximity Read ↗

Polymorphism of human cytochrome P450 enzymes and its clinical impact.Semantic proximity Read ↗

Cytochrome P450 Enzyme System: Genetic Polymorphisms and Impact on Clinical PharmacologySemantic proximity Read ↗

Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy.Semantic proximity Read ↗

Genetic polymorphism of cytochrome P450 and methods for its determination.Semantic proximity Read ↗

Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future.Semantic proximity Read ↗

Cytochrome P450 pharmacogenetics in African populations.Semantic proximity Read ↗

Cytochrome P450 variations in different ethnic populations.Semantic proximity Read ↗

Pharmacogenetics of drug metabolising enzymes: importance for personalised medicine.Semantic proximity Read ↗

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.