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Article

Genetic polymorphism of cytochrome P450. Functional consequences and possible relationship to disease and alcohol toxicity.

EXS - 1 Jan 1994

Ingelman-Sundberg M, Johansson I, Persson I, Oscarson M, Hu Y, Bertilsson L, Dahl M L, Sjöqvist F

Abstract excerpt

The hepatic cytochrome P450 system participates in the oxidative metabolism of numerous endogenous and exogenous compounds. In total several hundred different P450s have been cloned, but it appears that in humans only about 5-10 isoforms account for the major part of drug metabolism. Some of these are polymorphically distributed in the population. Cytochrome P450 2D6 catalyzes the oxidation of over 25 clinically...

Topics

Animals
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System
Enzyme Induction
Ethanol
Genetic Diseases, Inborn
Genotype
Humans
Liver Diseases, Alcoholic
Oxidoreductases, N-Demethylating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Predictive Value of Tests

Racial Groups

Source

Identifiers

PMID: 8032151
DOI: 10.1007/978-3-0348-7330-7_20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8032151-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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