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Article

Genetic susceptibility to adverse effects of drugs and environmental toxicants. The role of the CYP family of enzymes.

Mutation research - 1 Oct 2001

Ingelman-Sundberg M

Abstract excerpt

The majority of cytochrome P450 (CYP)-dependent xenobiotic metabolism is carried out by polymorphic and inducible enzymes which can cause abolished, quantitatively or qualitatively altered or enhanced drug metabolism. Stable duplication, multi-duplication or amplification of active genes, most likely in response to dietary components causing a selection of alleles with multiple genes, has been described. Several...

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Identifiers

PMID: 11535244
DOI: 10.1016/s0027-5107(01)00205-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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