Article
Cytochrome P450 polymorphisms and drug-induced interstitial lung disease.
Expert opinion on drug metabolism & toxicology - 1 Dec 2011
Schwaiblmair Martin, Behr Werner, Foerg Wolfgang, Berghaus Thomas
Abstract excerpt
INTRODUCTION: With an increasing number of therapeutic drugs available for use, the list of drugs that are responsible for severe pulmonary disease also grows. Genetic polymorphism of drug-metabolizing enzymes, particularly of the cytochrome P450 superfamily of enzymes, influences individual drug efficacy and safety through the alteration of pharmacokinetics and disposition of drugs. AREAS COVERED: This review...
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