Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids.

Abstract excerpt

Interaction of the human immunodeficiency virus type 1 (HIV-1) Rev protein with a structured region within env mRNA (termed RRE) mediates the export of virus structural mRNAs from the nucleus to the cytoplasm. We show that the region encompassing the basic stretch of amino acids is essential for the ability of Rev to bind to RRE RNA and function in vivo. By use of a functional truncated Rev protein in conjunction...

Topics

• Amino Acid Sequence
• Binding Sites
• Gene Expression Regulation, Viral
• Gene Products, rev
• Genes, env
• Genes, rev
• HIV-1
• Humans
• Macromolecular Substances
• Molecular Sequence Data