Function of the human immunodeficiency virus types 1 and 2 Rev proteins is dependent on their ability to interact with a structured region present in env gene mRNA.

doi:10.1128/JVI.64.9.4428-4437.1990

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Article

Function of the human immunodeficiency virus types 1 and 2 Rev proteins is dependent on their ability to interact with a structured region present in env gene mRNA.

Journal of virology - 1 Sept 1990

Dillon P J, Nelbock P, Perkins A, Rosen C A

Abstract excerpt

The interaction of the human immunodeficiency virus type 1 (HIV-1) Rev protein with a structured region in env mRNA (the Rev-responsive element [RRE]) mediates the export of structural mRNAs from the nucleus to the cytoplasm. We demonstrated that unlike HIV-1 Rev, which functions with both the HI...

Topics

Base Sequence
Binding Sites
Chromosome Deletion
Cloning, Molecular
Escherichia coli
Gene Products, rev
Genes, Viral
Genetic Vectors
HIV-1
HIV-2
Models, Molecular
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acid Conformation

Protein Binding

RNA, Messenger

Recombinant Proteins

Restriction Mapping

Source

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Identifiers

PMID: 2200888
DOI: 10.1128/JVI.64.9.4428-4437.1990
PMCID: PMC247912

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2200888-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Function of the human immunodeficiency virus types 1 and 2 Rev proteins is dependent on their ability to interact with a structured region present in env gene mRNA.PMID 2200888Read ↗

Secondary structure is the major determinant for interaction of HIV rev protein with RNA.Semantic proximity Read ↗

Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids.Semantic proximity Read ↗

Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.Semantic proximity Read ↗

Minimal Rev-response element for type 1 human immunodeficiency virus.Semantic proximity Read ↗

The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements.Semantic proximity Read ↗

HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence.Semantic proximity Read ↗

Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle.Semantic proximity Read ↗

Feedback regulation of human immunodeficiency virus type 1 expression by the Rev protein.Semantic proximity Read ↗

Binding of trans-dominant mutant Rev protein of human immunodeficiency virus type 1 to the cis-acting Rev-responsive element does not affect the fate of viral mRNA.Semantic proximity Read ↗

Human immunodeficiency virus rev protein recognizes a target sequence in rev-responsive element RNA within the context of RNA secondary structureSemantic proximity Read ↗

Mutational analysis of the HIV-1 Rev protein and its target sequence, the Rev responsive element.Semantic proximity Read ↗

Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis.Semantic proximity Read ↗

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