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Article

Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990

Cochrane A W, Chen C H, Rosen C A

Abstract excerpt

A region of potential complex secondary structure within the human immunodeficiency virus env mRNA has been implicated in Rev-mediated export of viral structural mRNAs from the nucleus to the cytoplasm. By using an RNase protection gel-mobility-shift assay, we demonstrate that purified Rev protein forms a stable complex with this Rev-responsive RNA. RNAs with mutations designed to disrupt formation of a predicted...

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Identifiers

PMID: 2405396
DOI: 10.1073/pnas.87.3.1198
PMCID: PMC53438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.PMID 2405396Read ↗

HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence.Semantic proximity Read ↗

Secondary structure is the major determinant for interaction of HIV rev protein with RNA.Semantic proximity Read ↗

Human immunodeficiency virus rev protein recognizes a target sequence in rev-responsive element RNA within the context of RNA secondary structureSemantic proximity Read ↗

Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids.Semantic proximity Read ↗

The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication.Semantic proximity Read ↗

Function of the human immunodeficiency virus types 1 and 2 Rev proteins is dependent on their ability to interact with a structured region present in env gene mRNA.Semantic proximity Read ↗

Minimal Rev-response element for type 1 human immunodeficiency virus.Semantic proximity Read ↗

Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein.Semantic proximity Read ↗

Feedback regulation of human immunodeficiency virus type 1 expression by the Rev protein.Semantic proximity Read ↗

Rev proteins of human and simian immunodeficiency virus enhance RNA encapsidation.Semantic proximity Read ↗

A specific sequence with a bulged guanosine residue(s) in a stem-bulge-stem structure of Rev-responsive element RNA is required for trans activation by human immunodeficiency virus type 1 Rev.Semantic proximity Read ↗

Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis.Semantic proximity Read ↗

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