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Article

Perturbation of the carboxy terminus of HIV-1 Rev affects multimerization on the Rev responsive element.

Biochemistry - 31 Aug 1993

Daly T J, Rennert P, Lynch P, Barry J K, Dundas M, Rusche J R, Doten R C, Auer M, Farrington G K

Abstract excerpt

Perturbations within the transactivation and carboxy-terminal domains of HIV-1 Rev were examined for effects on Rev responsive element (RRE) binding activities in vitro and biological activity in vivo. Binding affinities, specificities, and multimerization of the transactivation mutants M10 and Rev/Rex M10-16 on the RRE were equivalent to wild-type Rev. Substitution of the Rex transactivation domain within Rev...

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Identifiers

PMID: 8364040
DOI: 10.1021/bi00085a028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Perturbation of the carboxy terminus of HIV-1 Rev affects multimerization on the Rev responsive element.PMID 8364040Read ↗

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Real-time kinetics of HIV-1 Rev-Rev response element interactions. Definition of minimal binding sites on RNA and protein and stoichiometric analysis.Semantic proximity Read ↗

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