Article
Protein structure and oligomerization are important for the formation of export-competent HIV-1 Rev-RRE complexes.
Protein science : a publication of the Protein Society - 1 Mar 2008
Edgcomb Stephen P, Aschrafi Angelique, Kompfner Elizabeth, Williamson James R, Gerace Larry, Hennig Mirko
Abstract excerpt
The translation of the unspliced and partially spliced viral mRNAs that encode the late, structural proteins of HIV-1 depends on the viral-protein Rev. Oligomeric binding of Rev to the Rev response element (RRE) in these mRNAs promotes their export from the nucleus and thus controls their expression. Here, we compared the effects of hydrophobic to hydrophilic mutations within the oligomerization domain of Rev...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.