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Article

Unequal segregation of Neuralized biases Notch activation during asymmetric cell division.

Developmental cell - 1 Jul 2003

Le Borgne Roland, Schweisguth François

Abstract excerpt

In Drosophila, Notch signaling regulates binary fate decisions at each asymmetric division in sensory organ lineages. Following division of the sensory organ precursor cell (pI), Notch is activated in one daughter cell (pIIa) and inhibited in the other (pIIb). We report that the E3 ubiquitin ligase Neuralized localizes asymmetrically in the dividing pI cell and unequally segregates into the pIIb cell, like the...

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Identifiers

PMID: 12852858
DOI: 10.1016/s1534-5807(03)00187-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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