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Article

Cholangiocarcinomas can originate from hepatocytes in mice

16 Jul 2012

Abstract excerpt

Intrahepatic cholangiocarcinomas (ICCs) are primary liver tumors with a poor prognosis. The development of effective therapies has been hampered by a limited understanding of the biology of ICCs. Although ICCs exhibit heterogeneity in location, histology, and marker expression, they are currently thought to derive invariably from the cells lining the bile ducts, biliary epithelial cells (BECs), or liver...

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PMID: 22797301
DOI: 10.1172/jci63212

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