Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion

1 Apr 2016

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with poor prognosis and its incidence is increasing worldwide. Recently, several types of cells have been considered as the origin of ICC, namely cholangiocytes, liver progenitor cells, and hepatocytes. Here, we have established a novel mouse model of ICC by liver-specific Kras activation and Pten deletion. An activating mutation of Kras in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27032374
DOI: 10.1038/srep23899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletionPMID 27032374Read ↗

Cholangiocarcinomas can originate from hepatocytes in miceSemantic proximity Read ↗

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytesSemantic proximity Read ↗

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.Semantic proximity Read ↗

Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Notch2 controls hepatocyte-derived cholangiocarcinoma formation in miceSemantic proximity Read ↗

A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin‐4 in Tumor ProgressionSemantic proximity Read ↗

Oncogenic driver genes and tumor microenvironment determine the type of liver cancerSemantic proximity Read ↗

A novel mouse model of cholangiocarcinoma uncovers a role for a SOX17-Tensin 4 pathway in tumor progressionSemantic proximity Read ↗

Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humansSemantic proximity Read ↗

Activation of RAS/MEK/ERK signalling drives biliary differentiation in primary liver cancer.Semantic proximity Read ↗

Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors.Semantic proximity Read ↗

Kras and Tp53 Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.