Article

Oncogenic KRAS Requires Complete Loss of BAP1 Function for Development of Murine Intrahepatic Cholangiocarcinoma

2021-10-13

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is a primary biliary malignancy that harbors a dismal prognosis. Oncogenic mutations of KRAS and loss of function mutations of BRCA1-associated protein 1 ( BAP1 ) have been identified as recurrent somatic alterations in ICC. However, an autochthonous genetically engineered mouse model of ICC that genocopies the co-occurrence of these mutations has never been developed. By cr...

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Literature Corpus work: 6dfa4496-5930-5408-a1bb-0340a8ff03f9
DOI: 10.1101/2021.10.12.464103

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