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Article

Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2016

Moeini Agrin, Sia Daniela, Bardeesy Nabeel, Mazzaferro Vincenzo, Llovet Josep M

Abstract excerpt

Intrahepatic cholangiocarcinoma (iCCA) is a molecularly heterogeneous hepatobiliary neoplasm with poor prognosis and limited therapeutic options. The incidence of this neoplasm is growing globally. One third of iCCA tumors are amenable to surgical resection, but most cases are diagnosed at advanced stages with chemotherapy as the only established standard of practice. No molecular therapies are currently...

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Source

Identifiers

PMID: 26405193
DOI: 10.1158/1078-0432.CCR-14-3296

Genes

BAP1
BRAF
EGFR
FGFR2
IDH1
KRAS
ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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