Article
Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.
American journal of respiratory and critical care medicine - 1 Jun 2011
Leikauf George D, Concel Vincent J, Liu Pengyuan, Bein Kiflai, Berndt Annerose, Ganguly Koustav, Jang An Soo, Brant Kelly A, Dietsch Maggie, Pope-Varsalona Hannah, Dopico Richard A, Di Y P Peter, Li Qian, Vuga Louis J, Medvedovic Mario, Kaminski Naftali, You Ming, Prows Daniel R
Abstract excerpt
RATIONALE: Because acute lung injury is a sporadic disease produced by heterogeneous precipitating factors, previous genetic analyses are mainly limited to candidate gene case-control studies. OBJECTIVES: To develop a genome-wide strategy in which single nucleotide polymorphism associations are assessed for functional consequences to survival during acute lung injury in mice. METHODS: To identify genes associated...
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