Article
Association analysis reveals genetic variation altering bleomycin-induced pulmonary fibrosis in mice.
American journal of respiratory cell and molecular biology - 1 Mar 2013
Paun Alexandra, Lemay Anne-Marie, Tomko Tomasz G, Haston Christina K
Abstract excerpt
Pulmonary fibrosis is a disease of significant morbidity, with an incompletely defined genetic basis. Here, we combine linkage and association studies to identify genetic variations associated with pulmonary fibrosis in mice. Mice were treated with bleomycin by osmotic minipump, and pulmonary fibrosis was histologically assessed 6 weeks later. Fibrosis was mapped in C57BL6/J (fibrosis-susceptible) × A/J...
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