Article
Integrative genetic analysis of allergic inflammation in the murine lung.
American journal of respiratory cell and molecular biology - 1 Sept 2014
Kelada Samir N P, Carpenter Danielle E, Aylor David L, Chines Peter, Rutledge Holly, Chesler Elissa J, Churchill Gary A, Pardo-Manuel de Villena Fernando, Schwartz David A, Collins Francis S
Abstract excerpt
Airway allergen exposure induces inflammation among individuals with atopy that is characterized by altered airway gene expression, elevated levels of T helper type 2 cytokines, mucus hypersecretion, and airflow obstruction. To identify the genetic determinants of the airway allergen response, we employed a systems genetics approach. We applied a house dust mite mouse model of allergic airway disease to 151...
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