Article
Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.
PloS one - 1 Jan 2013
Himes Blanca E, Sheppard Keith, Berndt Annerose, Leme Adriana S, Myers Rachel A, Gignoux Christopher R, Levin Albert M, Gauderman W James, Yang James J, Mathias Rasika A, Romieu Isabelle, Torgerson Dara G, Roth Lindsey A, Huntsman Scott, Eng Celeste, Klanderman Barbara, Ziniti John, Senter-Sylvia Jody, Szefler Stanley J, Lemanske Robert F, Zeiger Robert S, Strunk Robert C, Martinez Fernando D, Boushey Homer, Chinchilli Vernon M, Israel Elliot, Mauger David, Koppelman Gerard H, Postma Dirkje S, Nieuwenhuis Maartje A E, Vonk Judith M, Lima John J, Irvin Charles G, Peters Stephen P, Kubo Michiaki, Tamari Mayumi, Nakamura Yusuke, Litonjua Augusto A, Tantisira Kelan G, Raby Benjamin A, Bleecker Eugene R, Meyers Deborah A, London Stephanie J, Barnes Kathleen C, Gilliland Frank D, Williams L Keoki, Burchard Esteban G, Nicolae Dan L, Ober Carole, DeMeo Dawn L, Silverman Edwin K, Paigen Beverly, Churchill Gary, Shapiro Steve D, Weiss Scott T
Abstract excerpt
Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with mouse AHR and human asthma-related phenotypes. Our goal was to identify asthma-related genes by integrating AHR associations in mouse with human genome-wide association study (GWAS) data. We...
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