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Article

Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts.

Developmental biology - 1 Mar 2012

Andersen Ryan O, Turnbull Doug W, Johnson Eric A, Doe Chris Q

Abstract excerpt

Drosophila neuroblasts are a model system for studying stem cell self-renewal and the establishment of cortical polarity. Larval neuroblasts generate a large apical self-renewing neuroblast, and a small basal cell that differentiates. We performed a genetic screen to identify regulators of neuroblast self-renewal, and identified a mutation in sgt1 (suppressor-of-G2-allele-of-skp1) that had fewer neuroblasts. We...

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Identifiers

PMID: 22248825
DOI: 10.1016/j.ydbio.2011.12.047
PMCID: PMC4013783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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