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Article

Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation.

Nature - 2 Feb 2006

Lee Cheng-Yu, Robinson Kristin J, Doe Chris Q

Abstract excerpt

How a cell chooses to proliferate or to differentiate is an important issue in stem cell and cancer biology. Drosophila neuroblasts undergo self-renewal with every cell division, producing another neuroblast and a differentiating daughter cell, but the mechanisms controlling the self-renewal/differentiation decision are poorly understood. Here we tested whether cell polarity genes, known to regulate embryonic...

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PMID: 16357871
DOI: 10.1038/nature04299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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