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Article

Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway

14 Apr 2023

Abstract excerpt

During periods of energetic stress, Caenorhabditis elegans can execute a developmentally quiescent stage called "dauer", during which all germline stem cells undergo a G2 cell cycle arrest. In animals that lack AMP-activated protein kinase (AMPK) signalling, the germ cells fail to arrest, undergo uncontrolled proliferation, and lose their reproductive capacity upon recovery from this quiescent stage. These...

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PMID: 37058536
DOI: 10.1371/journal.pgen.1010716

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