Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.

doi:10.1016/j.cell.2006.01.038

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Article

Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.

Cell - 24 Mar 2006

Betschinger Joerg, Mechtler Karl, Knoblich Juergen A

Abstract excerpt

How stem cells generate both differentiating and self-renewing daughter cells is unclear. Here, we show that Drosophila larval neuroblasts-stem cell-like precursors of the adult brain-regulate proliferation by segregating the growth inhibitor Brat and the transcription factor Prospero into only one daughter cell. Like Prospero, Brat binds and cosegregates with the adaptor protein Miranda. In larval neuroblasts,...

Topics

Animals
Brain
Cell Cycle Proteins
Cell Division
Cell Nucleus
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Gene Expression Regulation
Genes, Tumor Suppressor
Genes, myc
Humans
Larva
Mutation
Neoplasms
Nerve Tissue Proteins
Neurons
Nuclear Proteins

Source

Open in PubMed

Identifiers

PMID: 16564014
DOI: 10.1016/j.cell.2006.01.038

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