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Article

Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.

Cell - 24 Mar 2006

Betschinger Joerg, Mechtler Karl, Knoblich Juergen A

Abstract excerpt

How stem cells generate both differentiating and self-renewing daughter cells is unclear. Here, we show that Drosophila larval neuroblasts-stem cell-like precursors of the adult brain-regulate proliferation by segregating the growth inhibitor Brat and the transcription factor Prospero into only one daughter cell. Like Prospero, Brat binds and cosegregates with the adaptor protein Miranda. In larval neuroblasts,...

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PMID: 16564014
DOI: 10.1016/j.cell.2006.01.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.PMID 16564014Read ↗

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