Article

miR-190 is a Key Regulator in Establishing Cell Polarity and Specification in the Drosophila Nervous System

2025-05-28

Abstract excerpt

Asymmetric cell division generates cellular diversity in developing tissues, particularly in the CNS. In Drosophila neuroblasts, this process relies on polarity complexes and fate determinants, yet its molecular regulation remains unclear. Here, we identify miRNA-190 as a key regulator of neuroblast polarity and differentiation. Single-cell RNA sequencing and transcriptome analysis reveal that miR-190 deficiency...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c293f0b-1502-59e6-a335-5c0432638a2c
DOI: 10.1101/2025.05.28.656688

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

miR-190 is a Key Regulator in Establishing Cell Polarity and Specification in the Drosophila Nervous SystemDOI 10.1101/2025.05.28.656688Read

AGO1 in neural progenitor cells orchestrates brain development and sociability via LIN28A-REELIN axisSemantic proximity Read

Identification of Miranda protein domains regulating asymmetric cortical localization, cargo binding, and cortical release.Semantic proximity Read

Gliogenesis in Drosophila: genome-wide analysis of downstream genes of glial cells missing in the embryonic nervous system.Semantic proximity Read

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.Semantic proximity Read

Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural ProgenitorsSemantic proximity Read

miR-989 is required for border cell migration in the Drosophila ovary.Semantic proximity Read

The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer?Semantic proximity Read

MicroRNA-218 instructs proper assembly of hippocampal networksSemantic proximity Read

Ankle2, A Target of Zika Virus, Controls Asymmetric Cell Division of Neuroblasts and Uncovers a Novel Microcephaly PathwaySemantic proximity Read

A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell divisionSemantic proximity Read

Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression.Semantic proximity Read

MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastoma.Semantic proximity Read