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Article

LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jun 2009

Amin Nancy, Khan Afifa, St Johnston Daniel, Tomlinson Ian, Martin Sophie, Brenman Jay, McNeill Helen

Abstract excerpt

The serine-threonine kinase LKB1 regulates cell polarity from Caenorhabditis elegans to man. Loss of lkb1 leads to a cancer predisposition, known as Peutz-Jeghers Syndrome. Biochemical analysis indicates that LKB1 can phosphorylate and activate a family of AMPK- like kinases, however, the precise contribution of these kinases to the establishment and maintenance of cell polarity is still unclear. Recent studies...

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Identifiers

PMID: 19443685
DOI: 10.1073/pnas.0812469106
PMCID: PMC2690039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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