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Article

The p21-activated kinase Mbt is a component of the apical protein complex in central brain neuroblasts and controls cell proliferation.

Development (Cambridge, England) - 1 May 2013

Melzer Juliane, Kraft Karoline F, Urbach Rolf, Raabe Thomas

Abstract excerpt

The final size of the central nervous system is determined by precisely controlled generation, proliferation and death of neural stem cells. We show here that the Drosophila PAK protein Mushroom bodies tiny (Mbt) is expressed in central brain progenitor cells (neuroblasts) and becomes enriched to the apical cortex of neuroblasts in a cell cycle- and Cdc42-dependent manner. Using mushroom body neuroblasts as a...

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PMID: 23571212
DOI: 10.1242/dev.088435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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