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Article

Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia.

The Journal of cell biology - 8 Dec 2003

Rolls Melissa M, Albertson Roger, Shih Hsin-Pei, Lee Cheng-Yu, Doe Chris Q

Abstract excerpt

Cell polarity is essential for generating cell diversity and for the proper function of most differentiated cell types. In many organisms, cell polarity is regulated by the atypical protein kinase C (aPKC), Bazooka (Baz/Par3), and Par6 proteins. Here, we show that Drosophila aPKC zygotic null mutants survive to mid-larval stages, where they exhibit defects in neuroblast and epithelial cell polarity. Mutant...

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Identifiers

PMID: 14657233
DOI: 10.1083/jcb.200306079
PMCID: PMC2173607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia.PMID 14657233Read ↗

Kinase-activity-independent functions of atypical protein kinase C in Drosophila.Semantic proximity Read ↗

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The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells.Semantic proximity Read ↗

Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.Semantic proximity Read ↗

Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo.Semantic proximity Read ↗

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Requirement for Par-6 and Bazooka in Drosophila border cell migration.Semantic proximity Read ↗

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aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization.Semantic proximity Read ↗

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