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Article

Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia.

The Journal of cell biology - 8 Dec 2003

Rolls Melissa M, Albertson Roger, Shih Hsin-Pei, Lee Cheng-Yu, Doe Chris Q

Abstract excerpt

Cell polarity is essential for generating cell diversity and for the proper function of most differentiated cell types. In many organisms, cell polarity is regulated by the atypical protein kinase C (aPKC), Bazooka (Baz/Par3), and Par6 proteins. Here, we show that Drosophila aPKC zygotic null mutants survive to mid-larval stages, where they exhibit defects in neuroblast and epithelial cell polarity. Mutant...

Topics

Alleles
Animals
Carrier Proteins
Cell Cycle Proteins
Cell Division
Cell Polarity
Drosophila Proteins
Drosophila melanogaster
Epithelial Cells
Intracellular Signaling Peptides and Proteins
Larva

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons

Phenotype

Protein Kinase C

Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 14657233
DOI: 10.1083/jcb.200306079
PMCID: PMC2173607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia.PMID 14657233Read ↗

Kinase-activity-independent functions of atypical protein kinase C in Drosophila.Semantic proximity Read ↗

Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.Semantic proximity Read ↗

Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions.Semantic proximity Read ↗

The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells.Semantic proximity Read ↗

Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.Semantic proximity Read ↗

Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo.Semantic proximity Read ↗

Ankle2, A Target of Zika Virus, Controls Asymmetric Cell Division of Neuroblasts and Uncovers a Novel Microcephaly PathwaySemantic proximity Read ↗

Requirement for Par-6 and Bazooka in Drosophila border cell migration.Semantic proximity Read ↗

Drosophila aPKC is required for mitotic spindle orientation during symmetric division of epithelial cells.Semantic proximity Read ↗

An apical MRCK-driven morphogenetic pathway controls epithelial polarity.Semantic proximity Read ↗

aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization.Semantic proximity Read ↗

The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila.Semantic proximity Read ↗

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