Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential requirements for STRAD in LKB1-dependent functions in C. elegans.

Development (Cambridge, England) - 1 Feb 2010

Narbonne Patrick, Hyenne Vincent, Li Shaolin, Labbé Jean-Claude, Roy Richard

Abstract excerpt

The protein kinase LKB1 is a crucial regulator of cell growth/proliferation and cell polarity and is the causative gene in the cancer-predisposing disease Peutz-Jeghers syndrome (PJS). The activity of LKB1 is greatly enhanced following its association with the Ste20-like adapter protein STRAD. Unlike LKB1 however, mutations in STRAD have not been identified in PJS patients and thus, the key tumour suppressive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Body Patterning

Share to Caenorhabditis elegans Proteins

Share to Embryonic Stem Cells

Share to Genes, Helminth

Share to Germ Cells

Share to Peutz-Jeghers Syndrome

Source

Identifiers

PMID: 20110331
DOI: 10.1242/dev.042044

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential requirements for STRAD in LKB1-dependent functions in C. elegans.PMID 20110331Read ↗

Genome-wide surveys reveal polarity and cytoskeletal regulators mediate LKB1-associated germline stem cell quiescence.Semantic proximity Read ↗

Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling.Semantic proximity Read ↗

C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization.Semantic proximity Read ↗

LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye.Semantic proximity Read ↗

LKB1 and AMPK maintain epithelial cell polarity under energetic stress.Semantic proximity Read ↗

Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic NeoplasmsSemantic proximity Read ↗

Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.Semantic proximity Read ↗

DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferationSemantic proximity Read ↗

LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity.Semantic proximity Read ↗

Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathwaySemantic proximity Read ↗

The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry.Semantic proximity Read ↗

PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.