Article
Allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to Bacillus anthracis.
PLoS pathogens - 1 Dec 2011
Terra Jill K, France Bryan, Cote Christopher K, Jenkins Amy, Bozue Joel A, Welkos Susan L, Bhargava Ragini, Ho Chi-Lee, Mehrabian Margarete, Pan Calvin, Lusis Aldons J, Davis Richard C, LeVine Steven M, Bradley Kenneth A
Abstract excerpt
Anthrax is a potentially fatal disease resulting from infection with Bacillus anthracis. The outcome of infection is influenced by pathogen-encoded virulence factors such as lethal toxin (LT), as well as by genetic variation within the host. To identify host genes controlling susceptibility to anthrax, a library of congenic mice consisting of strains with homozygous chromosomal segments from the LT-responsive...
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