Article
Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1.
PLoS pathogens - 20 May 2010
Newman Zachary L, Printz Morton P, Liu Shihui, Crown Devorah, Breen Laura, Miller-Randolph Sharmina, Flodman Pamela, Leppla Stephen H, Moayeri Mahtab
Abstract excerpt
Anthrax lethal toxin (LT) is a bipartite protease-containing toxin and a key virulence determinant of Bacillus anthracis. In mice, LT causes the rapid lysis of macrophages isolated from certain inbred strains, but the correlation between murine macrophage sensitivity and mouse strain susceptibility to toxin challenge is poor. In rats, LT induces a rapid death in as little as 37 minutes through unknown mechanisms....
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