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Article

Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait loci.

The American journal of pathology - 1 Nov 2003

McAllister Ryan D, Singh Yogendra, du Bois Wendy D, Potter Michael, Boehm Thomas, Meeker Nathan D, Fillmore Parley D, Anderson Lisa M, Poynter Matthew E, Teuscher Cory

Abstract excerpt

Anthrax lethal toxin (LT) is the principal virulence factor associated with lethal pathologies following infection with Bacillus anthracis. Macrophages are the primary effector cells mediating lethality since macrophage-depleted mice are resistant to LT challenge. Recently, Ltxs1, the gene controlling differential susceptibility of murine macrophages to cytolysis following in vitro exposure to LT, was identified...

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Share to Antigens, Bacterial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14578173
DOI: 10.1016/S0002-9440(10)63532-8
PMCID: PMC1892420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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