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Article

Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii.

PLoS pathogens - 1 Mar 2014

Cirelli Kimberly M, Gorfu Gezahegn, Hassan Musa A, Printz Morton, Crown Devorah, Leppla Stephen H, Grigg Michael E, Saeij Jeroen P J, Moayeri Mahtab

Abstract excerpt

Toxoplasma gondii is an intracellular parasite that infects a wide range of warm-blooded species. Rats vary in their susceptibility to this parasite. The Toxo1 locus conferring Toxoplasma resistance in rats was previously mapped to a region of chromosome 10 containing Nlrp1. This gene encodes an inflammasome sensor controlling macrophage sensitivity to anthrax lethal toxin (LT) induced rapid cell death...

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Source

Open in PubMed Open full text

Identifiers

PMID: 24626226
DOI: 10.1371/journal.ppat.1003927
PMCID: PMC3953412

Genes

NLRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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