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Article

Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2010

Terra Jill K, Cote Christopher K, France Bryan, Jenkins Amy L, Bozue Joel A, Welkos Susan L, LeVine Steven M, Bradley Kenneth A

Abstract excerpt

Pathogenesis of Bacillus anthracis is associated with the production of lethal toxin (LT), which activates the murine Nalp1b/Nlrp1b inflammasome and induces caspase-1-dependent pyroptotic death in macrophages and dendritic cells. In this study, we investigated the effect of allelic variation of Nlrp1b on the outcome of LT challenge and infection by B. anthracis spores. Nlrp1b allelic variation did not alter the...

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Identifiers

PMID: 19949100
DOI: 10.4049/jimmunol.0903114
PMCID: PMC2811128

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Source receipt: pubmed, retrieved 7 Sept 2026.

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