Article
Evidence of gene-environment interaction for the RUNX2 gene and environmental tobacco smoke in controlling the risk of cleft lip with/without cleft palate.
Birth defects research. Part A, Clinical and molecular teratology - 1 Feb 2012
Wu Tao, Fallin M Daniele, Shi Min, Ruczinski Ingo, Liang Kung Yee, Hetmanski Jacqueline B, Wang Hong, Ingersoll Roxann G, Huang Shangzhi, Ye Xiaoqian, Wu-Chou Yah-Huei, Chen Philip K, Jabs Ethylin Wang, Shi Bing, Redett Richard, Scott Alan F, Murray Jeffrey C, Marazita Mary L, Munger Ronald G, Beaty Terri H
Abstract excerpt
This study examined the association between 49 markers in the Runt-related transcription factor 2 (RUNX2) gene and nonsyndromic cleft lip with/without cleft palate (CL/P) among 326 Chinese case-parent trios, while considering gene-environment (GxE) interaction and parent-of-origin effects. Five single-nucleotide polymorphisms (SNPs) showed significant evidence of linkage and association with CL/P and these...
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